biotech_express

genetics, biotechnology, Rifkin, genetic engineering, technology, nature, publications, gene, science, biology, scientists, patenting, Publishers, critics.

Of all the sceptics, Jeremy Rifkin has been the most visible in the media and the most maligned by the principal players in the new bio-academic-industrial complex.
A second work, Algeny, published in 1983, is a selective compendium of footnotes in the history of science that positions biotechnology within a neo-Darwinist Weltgeist and posits two paths to the future, one with genetic engineering and one without it.
Some of this complexity is acknowledged in the final chapter, "A personal note", in which Rifkin writes of using science, and even genetics, in a manner that respects our natural world: "the question is what kind of biotechnologies will we choose in the coming Biotech Century?"

ans_skulls_alive

skull, bone, sutures, adult, animals, eye, sea lion, infant, black-tailed deer, antlers, diseases, jaw, fishing, regenerate.

Just by looking at a skull, scientists (and YOU) can determine how long an animal lived, how healthy it had been during its life, and how it might have died.
FACT: The cranium of an animal is made up of a series of bony plates joined together by sutures.
Look for sutures on the adult and infant skulls.
Sutures allow the skull to be temporarily compressed during birth, allowing it to fit through the birth canal.
Sutures also allow the skull to grow, as all the bone growth of the skull occurs along the edges of the bony plates.
One of the animals in this case had a really bad toothache which was caused by an abscessed (or diseased) tooth.

alvin_kaye

estrogens, stimulation, cells, Kaye, SERMS, steroid, rats, vitamin, creatine kinase, analogs, estrogen receptor, estradiol, responsiveness, fragments.

Creatine kinase B as a marker of cell stimulation The brain type isozyme of creatine kinase (CKB), a cytosolic enzyme which catalyzes the reversible transfer of a high energy phosphate group between phosphocreatine and ADP, is involved in the regeneration of ATP and the buffering and transport of cellular energy.
Midregion fragments given daily to prepubertal rats, for two weeks, increased the thickness of the cortical bone in the humerus and the number of cells in the proliferating zone of the humeral growth plate.
Synergy between vitamin D and estrogens Our finding that pretreatment with vitamin D increases the anabolic responsiveness of skeletal derived cells to estrogen led to testing analogs of vitamin D which do not share its property of causing excess calcium deposits.

honig-speaker

protein-protein, complexes, binding, interfaces, polar, charges, residues, interactions, formation, electrostatics, sequence, specificity, polar groups, physical chemical/bioinformatics.

Scoring functions can be derived in a number of ways and have been based on the statistical properties of interfaces, e.g. the propensities of certain amino acids to be close to one another, and on physical chemical principles.
Protein-protein interactions have been studied in this way as well, however the problem of predicting the binding mode for two or more proteins appears to be considerably more difficult than for protein-small molecule interactions.
However in principle interfaces might have evolved to be nonpolar and hence to be similar to the interiors of the individual monomers.
In fact, the contrast between protein-protein complexes and folded proteins, which have large hydrophobic cores and tend not to bury many charged and polar group, is quite striking.

rr02_128

hypothalamus, organ, hormone, secrete, pituitary gland, transcription, cell, induction, BPES, forkhead/winged-helix, expression pattern, novel, signaling, phenotype.

Pituitary gland development serves as an excellent model system to address two of the central questions in mammalian organogenesis: where does an organ become determined within a common primordium, and how are the different cell types subsequently appearing.
The pituitary cell types express and secrete a series of trophic hormones which appear in distinct temporal and spatial patterns between day 14.5-16.5 of mouse embryogenesis.
Corticotropes secrete adrenocorticotropin hormone (ACTH); melanotropes secrete melanocyte-stimulating hormone (MSH); thyrotropes secrete thyroid-stimulating hormone (TSH); gonadotropes secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH); somatotropes secrete growth hormone (GH); and lactotropes secreting prolactin (Prl).
The hypothalamus is at center stage when it comes to regulation of food intake and energy expenditure.

ergongenicaids

substances, practices, ergogenic aids, athletes, competition, sport, preparation, nutritional substances, agents, clothing, hormones, equipment, train, training program.

It is probably safe to say that athletes have tried just about everything that can be consumed, practiced or worn to help them perform better.
And without a doubt the search for ergogenic aids will continue as long as humans seek to improve their physical abilities.
On the other side of the spectrum, ergolytic agents are substances and practices that are detrimental to performance and in many cases even health.
For most of us, probably the most important categories of ergogenic aids we can incorporate into our training and competition preparation fall into three areas: mechanical devises (equipment and clothing), nutritional substances and psychological preparation.

orphand2

drug, designation, indication, Sponsor, treatment, patients, Australia Pty, Pharmacia, peritoneal dialysis, disease, growth, dialysis solution, infection, thrombocytopenia.

Indication: for the treatment of patients with acute promyelocytic leukaemia, who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.
Indication: for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency (AIDS).
Indication: for the treatment of children (2 years and above) and adolescents with chronic hepatitis B and evidence of hepatitis B virus (HBV) replication.
Date of designation: 15/08/2002 Indication: for: Diagnostic scintigraphic localisation of tumours originating in tissue that embryologically stems from the neural crest.
Date of designation: 21/08/2002 Indication: the treatment of severe combined immunodeficiency X1 (SCID X1) Status: The orphan drug designation for this product was withdrawn on 2/10/2002.

Glossary

Health, Agriculture, Officer, spongiform encephalopathy, Environmental Health, Research Council, MAFF, protein, host, Fisheries, Committee, transmissible spongiform encephalopathy, meat, injection.

For fuller explanations of some of these terms, and of others elsewhere in the Report, see the main Glossary in vol. 16: Reference Materials (or via an electronic link in the website or CD-ROM versions).
HSE Health and Safety Executive IAH Institute for Animal Health i.c.
Intracerebral (into the brain -- by injection) i.p.
SAF Scrapie-associated fibril SBO Specified Bovine Offal: specified cattle tissues banned for consumption -- brain, spinal cord, spleen, thymus, tonsils and intestines Scrapie A transmissible spongiform encephalopathy endemic in British sheep.
SE Spongiform encephalopathy SEAC Spongiform Encephalopathy Advisory Committee.

IntellDishonesty

anti-aging, anti-aging medicine, aging, NIA, health, scientists, disease, hormone, therapy, physicians, science, practice, technology, NIA Fallacy.

American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net) The American Academy of Anti-Aging Medicine (A4M) is a not-for-profit medical society dedicated to the advancement of technology to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process.
This plan received its most fervent support by the aging establishment when in the year 2000 the National Institute on Aging (NIA) presented in their FY 2001-2005 Strategic Plan an agenda item to "Disseminate Accurate and Compelling Information to the Public, Scientific Community, and Health Care Professionals" [Subgoal 3, Goal D "Enhance Resources to Support High Quality Research," www.nih.giv/nia/strat-plan/2001-2005/7.htm.] In it, the NIA specifically mentions launching new "national education campaigns, such as a recent one that encouraged the public to seek more information about increasingly popular 'anti-aging therapies'."

full_length_guide

Technologies, sequence, pCMV6-XL4, gene, cDNA, clones, transcripts, promoter, tube, cells, filter, DNA, plasmid, reverse.

Having a gene sequence is one thing, but having a molecular clone of that gene is quite something else.
Analysis of the human genome sequence also confirmed previous suggestions that many human genes have alternative splicing of their RNA transcripts and that, on average, there are perhaps as many as 3-4 times more transcripts than there are genes.
The 'full-length' cDNA fragment is present in an expression vector with the open reading frame located downstream of a transcriptional promoter capable of driving heterologous gene expression in a variety of mammalian cell lines in culture and to support heterologous gene expression a variety of tissues in transgenic mice.
2401 ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa © OriGene® Technologies, Inc.
2501 tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga © OriGene® Technologies, Inc.

wadler

drugs, doping, sports, performance enhancing drugs, creatine, athletes, conference, substance, abuse, York University School, Medicine, strychnine, muscle, anabolic steroids.

An English cyclist died of an overdose of what is only known as "trimethyl", during a race between Bordeaux and Paris.
Of course, in the more than 100 intervening years, doping in sports, like the rest of technology, has grown in scientific and ethical complexity.
Our principle concern, as physicians, was, and is the proper use of drugs, not their abuse.
Remarkably, though the testing of horses for performance enhancing drugs dates back to 1910, the testing of humans for drug use in sports is a phenomenon of only the past quarter century.
All would agree, that in recent years, the physiologic substance creatine has been taken in large amounts by an extraordinary large number of athletes, a process called creatine loading.

sato

EGF receptor, mRNA, cells, thyroid hormone, epidermal growth, rat, truncated EGF receptor, hepatoma, RNA, regulation, Satoh, culture, Japan, DRB.

The 3' terminal region of full-length EGF receptor mRNA may have a role in the destabilization of EGF receptor mRNA by T3, because truncated EGF receptor mRNA lacks only the 3' terminal region of full-length EGF receptor mRNA.
For the measurement of stability of mRNA, the culture medium was changed to the fresh medium containing 65 m M DRB (Harrold et al., 1991; Sigma-Aldrich Japan K.K., Tokyo) and 3% DCC-NCS with or without 100 nM T3 and cells were cultured for an indicated time.
Northern blot analysis RNA was extracted from the cells by the acid guanidinium thiocyanate-phenol-chloroform method (Chomozynski and Sacchi, 1987) and was analyzed by Northern blot analysis as described previously (Satoh et al., 1997).

EducModifiedFreqreport

athlete, dietary supplements, drug testing, substances, Neu, competing, Dis, performance enhancing, Educational Program Development, Agr, Athlete Survey, prohibited substances, anabolic steroids, Disagree.

4 709 Other athletes communicating on the internet 2.50 50.5 34.0 15.5 are a good source of information on the benefits and risks of performance enhancing drugs and dietary supplements.
10 706 If the recommended dosage for using a dietary 1.68 89.5 7.9 2.5 supplement has beneficial effects, taking more is likely to have even greater benefits.
Your beliefs about drug testing in sport.
1 704 Drug testing athletes at events is a good idea.
2 704 I would be comfortable turning down a friend 4.43 2.0 3.4 94.6 who offered me a performance enhancing dietary supplement s/he said was safe.

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