Notify your doctor if you develop a rapid or pounding heartbeat, dizziness, trouble sleeping, shaking of the hands, tremors or unusual weakness while taking this medication.

This medication may cause dizziness. Use caution engaging in activities requiring alertness.

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Precautions:

This medication should be used only if clearly needed during pregnancy.

Discuss the risks and benefits with your doctor.

Since small amounts of this medication are found in breast milk, consult your doctor before breast-feeding.

Tell your doctor if you have a history of heart disease,thyroid disease, diabetes, high blood pressure, seizure disorder, glaucoma or if you have any allergies especially to sulfites.

The elderly and children may be more susceptible to the effects of this medication.

Use this with caution.

Generic Name: Phenylephrine

Neo-Synephrine 10 mg/ml Ampul - Prescription

Neo-Synephrine 10 mg/ml Disposable Syringe - Prescription

Phenylephrine HCl 10 mg/ml Vial - Prescription

Vicks Sinex 0.5% Aerosol, Mist - Over the counter

Neo-Synephrine 0.25% Aerosol, Spray - Over the counter

Neo-Synephrine 0.5% Aerosol, Spray - Over the counter

Vicks Sinex 0.5% Aerosol, Spray - Over the counter

Neo-Synephrine 1% Aerosol, Spray - Over the counter

Nostril 0.25% Aerosol, Spray w/Pump - Over the counter

Afrin Children's 0.25% Aerosol, Spray w/Pump - Over the counter

Nostril 0.5% Aerosol, Spray w/Pump - Over the counter

St. Joseph Nasal 0.125% Aerosol, Spray w/Pump - Over the counter

Alconefrin-12 0.16% Drops - Over the counter

Neo-Synephrine 0.5% Drops - Over the counter

Alconefrin-50 0.5% Drops - Over the counter

Neo-Synephrine 1% Drops - Over the counter

Phenylephrine HCl 1% Drops - Over the counter

569.pdf

Allergic contact reactions from phenylephrine are rare despite extensive use by ophthalmologists.
Previous reports do not indicate crossreactivity between phenylephrine and other sympathomimetic drugs in patch testing.
Conclusion: Phenylephrine was the responsible agent for the reactions in our patients as confirmed by clinical findings and positive patch tests.
The most frequent side effects of phenylephrine hydrochloride in eyedrops are blurred vision, burning or stinging, tearing, conjunctival irritation, liberation of iris pigment into the anterior chamber and corneal edema.
Phenylephrine hydrochloride is also employed in otic topical preparations to achieve decongestant effects, and in some rectal and vascular ointments.

Patch testing or epicutaneous testing is the diagnostic technique of applying a specific substance to the skin with the intention of producing a small area of allergic contact dermatitis. allergy, eyedrops.

JPET291-1999.pdf

Genetic polymorphisms in drug receptors, in particular adrenergic receptors, may contribute to intersubject differences in pharmacologic response.
Because response to phenylephrine depends upon interaction with a1B-adrenergic receptors, we tested whether polymorphisms in this receptor contribute to the variable responses.
Accordingly, we developed a polymerase chain reaction-based method, generating four exon-spanning fragments, to identify polymorphisms in the coding sequence of the two exons of the human a1B-adrenergic receptor.
PCR products of the human a1B-adrenergic receptor gene from human genomic DNA templets were subjected to electrophoresis on 1% Seakem GTG-agarose gels.

http://medicine.ucsd.edu/hypertension/PDF_publications/JPET291-1999.pdf
Lane A 1 B indicate exon 1 and lane C 1 D indicate exon 2 of the coding sequence of the human a1B-adrenergic receptor. a1B-adrenergic receptor, adrenergic receptors.

Vol87_No11_1380.pdf

Method: Patients at the Eye Clinic Srinagarind Hospital were randomized into two groups.
Pupil diameter, blood pressure and heart rate were measured before and after eyedrop instillation.
There was no significant difference in mean systolic and diastolic blood pressure after instillation between the two groups.
However, the mean heart rate after instillation in group 1 was greater than the value in group 2 with statistically significant difference.

In a prospective randomized double-blind clinical trial there was a large enough sample size to demonstrate that in darkly pigmented irides 10% phenylephrine appears to be more effective than 2.5% phenylephrine in pupillary dilation. phenylephrine, eyedrops.

76n-052n-sup0007-01-vol77.pdf

PEB is targeted to be included in Supplement 1 to USP 28-NF 23.
System suitability solutionDissolve accurately weighed quantities of USP Phenylephrine Hydrochloride RS, norphenylephrine hydrochloride, 1 -benzylphenylepherine benzylphenylepherine base, and hydrochloride in Diluent, and dilute quantitatively, and stepwise if necessary, to obtain a solution having known concentrations of about 0.06 mg per mL, 0.09 mg per mL, 0.07 mg per mL, and 0.05 mg per mL, respectively.
Chromatographic system (see Chromatography (621 I)equipped with a 215nm detector and a 55cm The liquid chromatograph is x 4-mm column that contains packing Ll.

http://www.fda.gov/ohrms/dockets/dailys/04/June04/062404/76n-052n-sup0007-01-vol77.pdf
The relative standard deviation for replicate chromatograms, and measure all of the peak responses. phenylephrine, Pharmacopeial Forum.

therapeutic_5200.pdf

For treatment of acute diffuse bacterial external otitis.
Criteria for coverage include: A. - failure to respond to other listed antibiotics, or B. - contraindications to other listed antibiotics.
A. - treatment of radiation mucositis and oral ulcerative complications of chemotherapy.

B. - use in immunocompromised patients who are at risk of mucosal breakdown. Ophth Solution, Health Canada.