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|  | VivactilSide
Effects:
May cause drowsiness, dizziness, increased sun sensitivity or blurred vision.
May initially cause dizziness and lightheadedness when rising too quickly
from a sitting or lying position. Other side effects include heartburn,
loss of appetite, dry mouth, strange taste in mouth, anxiety, restlessness or
sweating. These should subside as your body adjusts to the medication.
Notify your doctor if you develop chest pain,a rapid heart rate, difficulty urinating,
nightmares, ringing in the ears, excessive sedation, uncoordinated movements or
fainting. Taking this medication at bedtime may help minimize side effects.
Talk to your doctor about this. In the unlikely event you have an
allergic reaction to this drug, seek medical attention immediately. Symptoms
of an allergic reaction include rash, itching, swelling, dizziness or trouble
breathing. .
Precautions:
Before using this drug tell your doctor your medical history, especially of glaucoma,
prostate problems, decreased urine output, thyroid disease, breathing problems,
seizure problems, alcohol use, heart disease, mental/emotional problems, liver
or kidney disease and of any drug allergies. Use caution when engaging
in tasks requiring alertness such as driving or operating machinery. Limit
alcohol consumption as it may increase the drowsiness and dizziness effects of
this drug. Limit exposure to hot weather as it may lead to heat stroke.
This drug should be used during pregnancy only if clearly needed. Discuss
the risks and benefits with your doctor. This drug may be excreted into
breast milk. The effects on the infant are not known at this time. Consult
your doctor before breast-feeding. 
Generic
Name: Protriptyline HClRelated:
Vivactil 10 mg Tablet - Prescription
Protriptyline HCl 10 mg Tablet - Prescription
Vivactil 5 mg Tablet - Prescription
Protriptyline HCl 5 mg Tablet - Prescription
425
http://erj.ersjournals.com/cgi/reprint/8/3/425.pdf
patients, protriptyline, Pao2, COPD, placebo, life, hypoxaemia, arterial blood
gas, treatment, side-effects, exacerbations. Effect
of protriptyline, 10 mg daily, on chronic hypoxaemia in chronic obstructive pulmonary
disease.
ABSTRACT: A daily dose of 20 mg of protriptyline can improve
daytime arterial blood gas tensions in chronic obstructive pulmonary disease (COPD).
Twenty six patients were randomized to receive protriptyline or placebo in a double-blind
parallel-group trial for 12 weeks, following a run-in period of 4 weeks, in order
to assess the stability of hypoxaemia.
Laboratory evaluations There was
no significant impact by protriptyline or placebo on routine laboratory evaluations.
Three patients in the protriptyline group and two patients in the placebo group
experienced exacerbations of COPD during the trial (NS).
vivactil1200.pdfhttp://www.citizen.org/eletter/labeling/vivactil1200.pdf
patients, drug, VIVACTIL, tricyclic antidepressant, inhibit, overdose, dosage,
metabolizers, depression, dose, adverse reactions. VIVACTIL*
Tablets (Merck) (Protriptyline HCl) This product is marketed by Odyssey Pharmaceuticals,
a subsidiary of Sidmak Labs.
VIVACTIL is indicated for the treatment of
symptoms of mental depression in patients who are under close medical supervision.
Hyperpyretic crises, severe convulsions, and deaths have occurred in patients
receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously.
VIVACTIL should be used with caution in elderly patients and patients with cardiovascular
disorders; such patients should be observed closely because of the tendency of
the drug to produce tachycardia, hypotension, arrhythmias, and prolongation of
the conduction time.
Depending on the fraction of drug metabolized by
P450 2D6, the increase in plasma concentration may be small or quite large (8-fold
increase in plasma AUC of the TCA).
16012s38.pdfhttp://www.fda.gov/cder/ogd/rld/16012s38.pdf
drug, patients, VIVACTIL, tablets, Supplement, HCI, tricyclic antidepressant,
labeling, Agency, receiving, overdose. This sentence
is a repeat of information in PRECAUTIONS/ In formation for Patients and it reads:
"It may impair mental and/or physical abilities required for the performance
of hazardous tasks, such as operating machinery.
Supplement application
S-046 provides revision of the OVERDOSAGE section of labeling in response to an
Agency letter dated October 3, 1995, in order to describe current clinical toxicology
recommendations on how to best manage overdoses with tricyclic antidepressants.
VIVACTIL* (Protriptyline HCI) is supplied as 5 mg and 10 mg film coated tablets.
Hyperpyretic crises, severe convulsions, and deaths have occurred in patients
receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously.
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