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Ziac - is used to treat hypertension (high blood pressure).:
Side Effects:
You may experience dizziness, lightheadedness, drowsiness or blurred
vision as your body adjusts to the medication.
Use caution engaging in activities requiring alertness.
Because beta-blockers reduce blood circulation to the extremities,
your hands and feet may be more susceptible to cold.
Thiazide diuretics can cause potassium loss from the body.
It is advisable to eat foods or drink liquids high in potassium
such as citrus juice, bananas, melons, raisins and dates.
Use of salt substitutes also help prevent potassium loss.
Sometimes potassium supplement medication may be prescribed by
your doctor.
Inform your doctor if you develop breathing difficulty, easy bruising
or bleeding, swollen hands or feet, confusion or depression, excessive
thirst, muscle cramps, yellowing of the eyes or skin or a sore throat
while taking this medication.
This medication may increase sensitivity to the sun.
Avoid prolonged sun exposure.
Wear protective clothing and use a sunscreen. 
Precautions:
You may want to check your pulse everyday while taking this drug.
Discuss with your doctor what changes in your pulse rate mean.
Use during pregnancy only if clearly needed.
Small amounts of this medication appear in breast milk. Discuss
breast-feeding with your doctor.
Tell your doctor if you are allergic to sulfa drugs.
You may also be allergic to this medication.
For information on Medic Alert(TM) call 1-800-854-1166.
In Canada call 1-800-668-1507. 
Related Drugs:
Ziac 6.25-2.5 mg Tablet - Prescription
Ziac 6.25-5 mg Tablet - Prescription
Ziac 6.25-10 mg Tablet - Prescription , 

Generic Name: HCTZ/Bisoprolol Fumarate
dZiac_PI
http://www.fda.gov/medwatch/SAFETY/2003/03Jan_labels/Ziac_PI.pdf
bisoprolol fumarate, doses, patients, hydrochlorothiazide,
Ziac, agents, HCTZ, administration, therapy, tablets, treatment,
decreases, adverse, electrolyte.
ZIAC (bisoprolol fumarate and hydrochlorothiazide) is
indicated for the treatment of hypertension.
Bisoprolol fumarate is a beta 1-selective (cardioselective) adrenoceptor
blocking agent without significant membrane stabilizing or intrinsic
sympathomimetic activities in its therapeutic dose range.
Because of its beta1-selectivity, this is less likely with bisoprolol
fumarate.
However, patients subject to spontaneous hypoglycemia, or diabetic
patients receiving insulin or oral hypoglycemic agents, should be
cautioned about these possibilities.
Miscellaneous: The oculomucocutaneous syndrome associated with the
beta-blocker practolol has not been reported with bisoprolol fumarate
during investigational use or extensive foreign marketing experience.
The following adverse experiences, in addition to those listed in
the above table, have been reported with hydrochlorothiazide (generally
with doses of 25 mg or greater).

dubachchf
ventricular, patients, therapy, exercise, rotation, cardiac,
beta-blockade, placebo, bisoprolol fumarate, techniques, ejection
fraction, MRI, motion, end-diastole.
Background Recent data suggest that beta-blockers can
be beneficial in subgroups of patients with chronic heart failure
(CHF).
We examined the effects of bisoprolol fumarate on exercise capacity
and left ventricular volume with magnetic resonance imaging (MRI)
and applied a novel high-resolution MRI tagging technique to determine
myocardial rotation and relaxation velocity.
Statistical Graphics Corporation software (Bethesda, Md) was used
to perform multivariante analysis of variance procedures between
patients randomized to bisoprolol fumarate or placebo.
Sample size estimates were on the basis of variance obtained from
our previous studies of ventricular volumes with MRI, in which the
standard deviation of left ventricular end-diastolic volume was
roughly 40 mL.

03008news
http://www.hlth.gov.bc.ca/pharme/newsletter/03008news.pdf
Tab, PharmaCare, PMS, drug, APX, Rhoxal-Pravastatin Tab,
RXP, LCA, special authority, PharmaCare newsletter, resubmission,
Pms-Carvedilol Tab, Apo-Carvedilol Tab, Ratio-Paroxetine Tab.
PharmaCare program for British Columbia's community pharmacists.
8:00am to 4:00pm, Saturday and Sunday Registration via the Web and
IVR continue to be available outside these hours.
PharmaCare currently has two Acting Executive Directors, Phyllis
Chuly and Suzanne Solven.
Suzanne is responsible for policy related to drug benefit decisions,
the special authorization process and Federal/Provincial/Territorial
initiatives related to the Common Drug Review, generic drug harmonization
and best practices.
Please forward inquiries to the appropriate A/Executive Director.
Drug Name correction Addition to new booklet.

ij_dop_0200
http://www.locumusa.com/pdf/members/ij_dop_0200.pdf
patent, drugs, exclusivity, Expiry, expiration, Marketer,
USD, NCE, Hcl, CODES, Holder, Trade, Johnson, Pharmacia.
dollar share from 11.4 in 1994 to 8.7 in 1998, an increase
in the number of generics per blockbuster or major product being
approved in the first year and pressures from healthcare payers
make it increasing important to analyse your R&D organisation's
effectiveness.
Note: Some Brand leader drugs products have been omitted due to
non-availability of sales data which will appear in the 2000/2001
DOP Report.
Delaying Tactics: FDA interpretation of the paediatric six month
exclusivity provisions of the FDA Modernization Act has additionally
extended the patent protection for ALL DOSAGE FORMS of the drug
not just the drug product used in the paediatric clinical trials.

wodsep99
http://www.uiowa.edu/~idis/wodsep99.pdf
patients, treatment, drug, pharmacy, IDIS, heart failure,
beta-blockers, ACE inhibitors, diuretics, chronic heart failure,
metoprolol, therapy, mortality, NYHA class.
Directions for obtaining continuing education credit
for this issue's article, "Beta-blockers in chronic heart failure,"
appear on page 6.
List the characteristics of heart failure patients that would be
favorable to benefit from the use of beta-blockers.
Generally the contraindications to the use of beta-blockers include
sinus node dysfunction, heart rate less than 50 beats per minute,
second- or thirddegree heart block (without a pacemaker), bronchospastic
disease, acutely decompensated heart failure until stabilized and
systolic blood pressure less than 100 mmHg.
To limit your search further, combine the drug of interest in the
Drug field and FAILURE, HEART, CONGESTIVE 428.0 in the Disease field.


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